KPV is a potent, naturally occurring tripeptide (Lysine-Proline-Valine) derived from -melanocyte-stimulating hormone (-MSH) that acts as a powerful anti-inflammatory and antimicrobial agent. It is widely used to treat chronic inflammation, specifically in the gut (IBS, Crohn’s, colitis) and skin.
How it works
- Inhibit NF-κB signaling (a key inflammation pathway)
- Reduce pro-inflammatory cytokines
- Work independently of melanocortin receptors in some models
- Act locally in tissues rather than systemically
Importantly, it does not significantly stimulate pigmentation, which full α-MSH can.
Potential benefits
- Reduced inflammatory markers
- Improved skin barrier repair
- Protection of gut lining integrity
- Minimal systemic side effects
Disclaimer: This is for research and informational purposes only. Our products are not for human consumption. For medical advice or diagnosis, consult a professional.
